Proliferative Verrucous Leukoplakia: A Diagnostic Perplexity
Published: 2021-08-04
Page: 149-154
Issue: 2021 - Volume 4 [Issue 2]
Nidhi Sinha *
Department of Oral Pathology and Microbiology, College of dental sciences BBD University, Lucknow, Uttar Pradesh, India.
Meghanand T. Nayak
Department of Oral Pathology and Microbiology, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Mooradabad, Uttar Pradesh, India.
Shreya Gupta
Oral Pathology and Microbiology, Content strategist, RELX India Pvt. Ltd, Gurgaon, Harayana, India.
Devangi Dwivedi
Department of Oral Pathology and Microbiology, College of dental sciences BBD University, Lucknow, Uttar Pradesh, India.
Neeti Swarup
Department of Oral Pathology and Microbiology, School of Dentistry, Seoul National University, South Korea.
Mansi Agarwal
Department of Oral Pathology and Microbiology, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Mooradabad, Uttar Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Proliferative verrucous leukoplakia (PVL) is an uncommon pathological lesion which is defined as a diffuse, white and smooth or papillary or wart-like exophytic growth of oral mucosa showing capricious degrees of epithelial hyperplasia. Initially, the lesion shows focal clinical hyperkeratosis that gradually becomes a comprehensive multifocal disease. In its primary stages, the lesion clinically is bland that it is often diagnosed as frictional hyperkeratosis or hyperplastic candidiasis, but with its descriptive natural features of chronic proliferation, copious occurrences, refractoriness to treatment and high rate of malignant transformation, it can be positively diagnosed as oral proliferative verrucous leukoplakia (OPVL).
Keywords: Exophytic growt, multifocal disease, refractoriness, malignant transformation